Endocrine Abstracts

Background: The phaeochromocytoma of the adrenal gland scaled score (PASS) is used for histological reporting of phaeochromocytomas as a surrogate marker of malignant potential. A PASS score of ≥4 (of a maximum of 20) suggests an aggressive tumour and hence the importance of lifelong careful follow-up. However, the utility of the PASS score has been questioned recently due to the discordance between PASS score and clinical outcomes.Aim: To review t...

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

Context: The immune checkpoint inhibitor (ICI) therapy is frequently used to treat advanced cancers. Autoimmune adverse events have been reported, such as endocrine side effects including frequent thyroid disorders and more rarely hypophysitis. The aim of this study was to describe retrospectively the association thyroiditis-hypophysitis.Patients and method: From 99 patients with endocrine side effects of the ImmuCare cohort, 18 patients with hypophysiti...

Background: Acromegaly is a rare disease with a long and complex diagnostic pathway leading to a substantial diagnostic delay associated with an increased risk of comorbidities and psychosocial deterioration. Qualitative methods are the gold standard to explore patients’ perspectives, focusing on how individuals understand and report what they are experiencing. To the best of our knowledge, no qualitative study has yet examined the diagnostic pathway of subjects with acro...

Aim: The aim of investigation to study of the features of the Cushing’s subclinical syndrome in women (CS) with metabolic syndrome (MS)Material and methods: Under our supervision in the Department of neuroendocrinology of the Center of Endocrinology of MPH out-patient clinics with primary or secondary infertility in the period from September 2015 to July 2016 were examined 120 patients of childbearing age with metabolic syndrome in polycystic ovary ...

Patients with Adrenal Insufficiency are potentially at risk of life threatening events if during intercurrent illness they do not take adequate glucocorticoid replacement. The National Institute for Health and Care Excellence Clinical Knowledge Summaries for this patient group recommend that they should: know how to self inject intramuscular hydrocortisone in an emergency; how to adjust their steroid replacement in response to illness; understand the importance of medical iden...

Background and aims: Polycystic Ovary syndrome (PCOS) is a common, lifelong condition. Its associated symptoms have been linked with psychological consequences, but less attention has been given to the daily implications of living with the condition. We aimed to explore women’s experiences of living with PCOS, including a specific focus on practical implications and methods of providing support such as structured group-based patient education.Method...

Background: Electronic endocrinology advice and Guidance (e-Endo A&G) via NHS e-Referral Service was introduced at University Hospitals of Leicester NHS Trust (UHL) in March 2017 to address General Practitioners’ (GP) non-urgent endocrinology clinical concerns. Primary aims of the service, was to prevent inappropriate outpatient visits, avoid acute admissions and reducing length of time in resolution of queries.Objectives: To retrospectively eva...

Background: The benefits of patient education in women with polycystic ovary syndrome (PCOS) are known but a cost effective way to offer the education to these patients need to be assessed. As part of a quality improvement project in an outpatient setting we tested the idea of incorporating group education for women with PCOS in their routine care process. We tested two different methods.Methods: 1. January-June 2017: Ad hoc open patient invitation<p...

Background: LHX4 encodes a member of the LIM-homeodomain transcription factor protein family that is required for development of the pituitary gland. To date, only incompletely penetrant heterozygous mutations in LHX4 have been described in patients with variable combined pituitary hormone deficiencies (CPHD).Objective/hypothesis: To investigate a cohort of patients with congenital hypopituitarism for mutations in LHX4.<p c...